Grand rounds 2.09
1. A previously completely healthy girl developed PVB19 infection leading to both encephalitis and aplastic anemia (possible, but highly unlikely, and, even if PVB19 were found, it would be far more likely that it was able to cause anemia because of immunosuppression due to AIDS).
2. This same girl also developed an acute allergic reaction to amoxicillin that led to cardiovascular collapse and--oh, by the way--also caused steatosis of the liver within a day after starting the drug, the steatosis being something even Dr. Al-Bayati's own references do not seem to support as being likely.
3. This same otherwise healthy girl had sufficient quantity of P. carinii in her lungs to show up on Gomori methenamine silver staining at her autopsy.
4. The medical examiner and neuropathologist either botched the staining for the p24 protein (or that it was a false positive) and an experienced neuropathologist didn't know the pitfalls of the diagnosis of HIV encephalitis using brain tissue sections.
Other grand rounds posts that caught my eye include this one reminding us that heart attacks are the leading cause of death in women (with a link to the story of a near-fatal heart attack in a 37-year-old woman); posts at Parallel Universes on a connection between antibiotic use and non-Hodgkins lymphoma (and an update), and a rant on Science Creative Quarterly about people who wear their lab coats and scrubs out in public (I don't get that one, either!). Lots of good reading this week.